Pioglitazone


w262



General information:


Withdrawn ID: w262
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): A10BG03
Molecular Formula: C19H20N2O3S
Molweight: 356.439



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1999
First withdrawn: 2011
Last withdrawn: 2011
Reference: https://www.ncbi.nlm.nih.gov/pubmed/26197187



Side-effects:

Total reported cases (submitted by medical professionals) with Pioglitazone as primary suspect: 9034


Reported final outcomes:
Hospitalization (initial or prolonged): 1406
Death: 1326
Intervention required to prevent permanent impairment/damage: 1155
Life-Threatening condition: 301
Disability: 124
Congenital anomaly: 7


Reported side-effects:

Side-effect Case number
BLADDER CANCER6249
DEATH457
BLADDER TRANSITIONAL CELL CARCINOMA438
CARDIAC FAILURE CONGESTIVE253
DYSPNOEA216
OEDEMA PERIPHERAL214
WEIGHT INCREASED198
HAEMATURIA176
CARDIAC FAILURE151
FALL131
HYPOGLYCAEMIA130
OEDEMA117
MYOCARDIAL INFARCTION114
BLOOD GLUCOSE INCREASED107
CONDITION AGGRAVATED77
DIZZINESS76
PLEURAL EFFUSION75
BLADDER CANCER RECURRENT73
ANAEMIA70
NAUSEA69
CHEST PAIN69
URINARY TRACT INFECTION66
ASTHENIA65
PROSTATE CANCER64
FATIGUE63
PULMONARY OEDEMA61
FLUID RETENTION61
DIABETES MELLITUS INADEQUATE CONTROL61
METASTATIC CARCINOMA OF THE BLADDER60
MALAISE59
BLADDER NEOPLASM58
BACK PAIN56
PAIN54
WEIGHT DECREASED52
HEADACHE52
VOMITING51
PNEUMONIA47
DYSURIA46
DIARRHOEA46
DRUG INEFFECTIVE45
ABDOMINAL PAIN45
BLOOD URINE PRESENT44
ACUTE MYOCARDIAL INFARCTION44
TRANSITIONAL CELL CARCINOMA43
RENAL FAILURE43
RENAL CANCER43
DRUG HYPERSENSITIVITY43
CEREBROVASCULAR ACCIDENT43
PAIN IN EXTREMITY41
ATRIAL FIBRILLATION41
POLLAKIURIA39
MYALGIA39
DECREASED APPETITE39
DYSPNOEA EXERTIONAL38
MACULAR OEDEMA37
ARTHRALGIA37
GLYCOSYLATED HAEMOGLOBIN INCREASED36
BLOOD GLUCOSE DECREASED34
RENAL IMPAIRMENT33
MEDICATION ERROR33
CARDIOMEGALY33
VISION BLURRED32
HYPERTENSION32
DRUG INTERACTION32
CYSTITIS32
Acute kidney injury32
MICTURITION URGENCY31
HYPERGLYCAEMIA31
COUGH31
PHARMACEUTICAL PRODUCT COMPLAINT30
RENAL FAILURE ACUTE29
TREATMENT NONCOMPLIANCE28
LOSS OF CONSCIOUSNESS28
CONFUSIONAL STATE28
URETERIC CANCER27
THROMBOCYTOPENIA27
PERICARDIAL EFFUSION27
INCORRECT DOSE ADMINISTERED27
PANCREATIC CARCINOMA26
HYPOAESTHESIA26
CARDIAC DISORDER26
ALANINE AMINOTRANSFERASE INCREASED26
RASH25
JOINT SWELLING25
HYPONATRAEMIA24
HYPERHIDROSIS24
GAIT DISTURBANCE24
PALPITATIONS23
LACTIC ACIDOSIS23
INTERSTITIAL LUNG DISEASE23
GENERALISED OEDEMA23
ASPARTATE AMINOTRANSFERASE INCREASED23
URINARY INCONTINENCE22
SWELLING22
PYREXIA22
NEPHROLITHIASIS22
HYPOTENSION22
HAEMOGLOBIN DECREASED22
DEHYDRATION22
VISUAL ACUITY REDUCED21
SEPSIS21
RHABDOMYOLYSIS21
MUSCULAR WEAKNESS21
METASTASES TO LUNG21
LIVER FUNCTION TEST ABNORMAL21
DRUG DISPENSING ERROR21
CORONARY ARTERY DISEASE21
URTICARIA20
RESPIRATORY FAILURE20
Peripheral swelling20
JAUNDICE20
DIABETIC RETINOPATHY20
DEPRESSION20
BLOOD PRESSURE INCREASED20
ASCITES20
SYNCOPE19
PLATELET COUNT DECREASED19
LIVER DISORDER19
HYPERKALAEMIA19
GASTROINTESTINAL DISORDER19
CHOLELITHIASIS19
TREMOR18
TACHYCARDIA18
NEUTROPENIA18
METASTASES TO LIVER18
LETHARGY18
HIP FRACTURE18
FLUID OVERLOAD18
FEELING ABNORMAL18
CORONARY ARTERY OCCLUSION18
ABDOMINAL PAIN UPPER18
NEOPLASM MALIGNANT17
INSOMNIA17
HYPOGLYCAEMIC COMA17
HEPATITIS17
HEPATIC CIRRHOSIS17
CHEST DISCOMFORT17
BLOOD CREATININE INCREASED17
BLADDER CANCER STAGE II17
ACUTE PULMONARY OEDEMA17
ABDOMINAL PAIN LOWER17
URINARY RETENTION16
PANCREATITIS16
LUNG NEOPLASM MALIGNANT16
HEPATIC FAILURE16
FACE OEDEMA16
CARDIAC ARREST16
WHITE BLOOD CELL COUNT DECREASED15
RENAL CYST15
PARAESTHESIA15
NOCTURIA15
METASTASES TO LYMPH NODES15
DEPRESSED LEVEL OF CONSCIOUSNESS15
CARDIAC FAILURE ACUTE15
BRONCHITIS15
BLOOD ALKALINE PHOSPHATASE INCREASED15
BENIGN PROSTATIC HYPERPLASIA15
ANKLE FRACTURE15
ABDOMINAL DISTENSION15
TIBIA FRACTURE14
RETINAL HAEMORRHAGE14
PRURITUS14
NO ADVERSE EVENT14
METASTASES TO BONE14
HYPERSENSITIVITY14
HAEMORRHAGE14
HAEMATOCRIT DECREASED14
EJECTION FRACTION DECREASED14
CONSTIPATION14
ANXIETY14
ANGINA PECTORIS14
WHEEZING13
ROAD TRAFFIC ACCIDENT13
RIB FRACTURE13
RENAL DISORDER13
PRODUCT SUBSTITUTION ISSUE13
HYPOKALAEMIA13
HEPATIC STEATOSIS13
FEMUR FRACTURE13
BLOOD CREATINE PHOSPHOKINASE INCREASED13
BLADDER DISORDER13
ANOREXIA13
OVERDOSE12
Off label use12
MEMORY IMPAIRMENT12
HEART RATE INCREASED12
ERYTHEMA12
Diabetic metabolic decompensation12
CARDIOMYOPATHY12
BREAST CANCER12
ARRHYTHMIA12
SPINAL COMPRESSION FRACTURE11
RADIUS FRACTURE11
OSTEOPOROSIS11
ORTHOPNOEA11
MUSCLE SPASMS11
MOBILITY DECREASED11
LEFT VENTRICULAR DYSFUNCTION11
KIDNEY INFECTION11
HYDRONEPHROSIS11
HOSPITALISATION11
GAMMA-GLUTAMYLTRANSFERASE INCREASED11
FRACTURE11
DIALYSIS11
DELIRIUM11
DEEP VEIN THROMBOSIS11
CATARACT11
BRAIN NATRIURETIC PEPTIDE INCREASED11
BRADYCARDIA11
ABDOMINAL DISCOMFORT11
ABASIA11
TRANSIENT ISCHAEMIC ATTACK10
SUICIDE ATTEMPT10
PULMONARY CONGESTION10
METASTASES TO KIDNEY10
MENTAL STATUS CHANGES10
LUMBAR VERTEBRAL FRACTURE10
INCONTINENCE10
HERPES ZOSTER10
HEPATIC ENZYME INCREASED10
GENERAL PHYSICAL HEALTH DETERIORATION10
FOOT FRACTURE10
DIABETIC KETOACIDOSIS10
CORONARY ARTERY STENOSIS10
COLON CANCER10
CELLULITIS10
BLOOD UREA INCREASED10
BLOOD BILIRUBIN INCREASED10
BLADDER TRANSITIONAL CELL CARCINOMA STAGE III10
BLADDER CANCER STAGE 0, WITH CANCER IN SITU10
ALTERED STATE OF CONSCIOUSNESS10
VENTRICULAR EXTRASYSTOLES9
TACHYPNOEA9
SUDDEN DEATH9
SPINAL FRACTURE9
RENAL CELL CARCINOMA9
PULMONARY HYPERTENSION9
OSTEOARTHRITIS9
ORTHOSTATIC HYPOTENSION9
OROPHARYNGEAL PAIN9
MITRAL VALVE INCOMPETENCE9
INFECTION9
HAEMATOMA9
GASTROINTESTINAL HAEMORRHAGE9
FIBULA FRACTURE9
EYE HAEMORRHAGE9
ERECTILE DYSFUNCTION9
Contraindicated product administered9
CEREBRAL INFARCTION9
BLOOD TRIGLYCERIDES INCREASED9
ANGIOEDEMA9
ANGINA UNSTABLE9
VISUAL IMPAIRMENT8
URETHRAL CANCER8
THROMBOSIS8
THIRST8
SWELLING FACE8
Sopor8
SHOCK8
POLYDIPSIA8
PITTING OEDEMA8
METABOLIC ACIDOSIS8
LEUKOPENIA8
IRON DEFICIENCY ANAEMIA8
HYPOXIA8
GASTRIC CANCER8
FEMORAL NECK FRACTURE8
ELECTROCARDIOGRAM QT PROLONGED8
DIABETIC NEUROPATHY8
CONVULSION8
CHROMATURIA8
CHILLS8
BLOOD PRESSURE SYSTOLIC INCREASED8
BLOOD POTASSIUM DECREASED8
BLISTER8
BLADDER PAPILLOMA8
BLADDER CANCER STAGE III8
BLADDER ADENOCARCINOMA STAGE UNSPECIFIED8
ACUTE RESPIRATORY FAILURE8
Abnormal weight gain8
VITREOUS HAEMORRHAGE7
VERTIGO7
VENTRICULAR HYPERTROPHY7
URINE FLOW DECREASED7
THORACIC VERTEBRAL FRACTURE7
SWOLLEN TONGUE7
SKIN ULCER7
SINUS TACHYCARDIA7
SEPTIC SHOCK7
RETINAL EXUDATES7
RETINAL ANEURYSM7
RENAL FAILURE CHRONIC7
PULMONARY EMBOLISM7
PRODUCTIVE COUGH7
POLYURIA7
Ovarian cancer7
OSTEOPENIA7
NEUROPATHY PERIPHERAL7
MYOCARDIAL ISCHAEMIA7
LEFT VENTRICULAR HYPERTROPHY7
HEPATOTOXICITY7
FLATULENCE7
DRUG EFFECT DECREASED7
Disturbance in attention7
CONTUSION7
COMA7
CHRONIC OBSTRUCTIVE PULMONARY DISEASE7
BLOOD POTASSIUM INCREASED7
BLADDER TRANSITIONAL CELL CARCINOMA STAGE II7
ATRIAL FLUTTER7
ARTHRITIS7
AORTIC STENOSIS7
ADVERSE EVENT7
ABORTION SPONTANEOUS7
VISUAL DISTURBANCE6
VENOUS PRESSURE JUGULAR INCREASED6
UPPER LIMB FRACTURE6
TRICUSPID VALVE INCOMPETENCE6
TRANSAMINASES INCREASED6
TOOTH DISORDER6
SPEECH DISORDER6
Sleep talking6
RIGHT VENTRICULAR FAILURE6
RESPIRATORY TRACT INFECTION6
REFUSAL OF TREATMENT BY PATIENT6
RECTAL CANCER6
PRESCRIBED OVERDOSE6
PREGNANCY6
POST PROCEDURAL COMPLICATION6
PERICARDITIS6
PANCYTOPENIA6
PANCREATITIS ACUTE6
PANCREATIC CARCINOMA METASTATIC6
NASOPHARYNGITIS6
MUSCULOSKELETAL PAIN6
MIGRAINE6
MATERNAL DRUGS AFFECTING FOETUS6
Malignant neoplasm of renal pelvis6
LYMPHADENOPATHY6
Localised oedema6
LOCAL SWELLING6
INTERNATIONAL NORMALISED RATIO INCREASED6
Intentional overdose6
INFLUENZA6
INFLAMMATION6
HYPERTHYROIDISM6
HAND FRACTURE6
Hallucination, auditory6
Gallbladder neoplasm6
DYSPEPSIA6
DRUG PRESCRIBING ERROR6
DRUG EXPOSURE DURING PREGNANCY6
DRUG ERUPTION6
DISEASE RECURRENCE6
DIFFICULTY IN WALKING6
DIABETIC NEPHROPATHY6
DIABETES MELLITUS6
COMPRESSION FRACTURE6
COMPLETED SUICIDE6
CARDIOVASCULAR DISORDER6
CARDIO-RESPIRATORY ARREST6
CARDIAC STRESS TEST ABNORMAL6
CARDIAC FAILURE CHRONIC6
BREAST CANCER FEMALE6
Bone pain6
BONE DISORDER6
BLOOD PRESSURE DECREASED6
BLINDNESS6
BLADDER TRANSITIONAL CELL CARCINOMA STAGE I6
BLADDER MASS6
BALANCE DISORDER6
ATELECTASIS6
Apathy6
AGITATION6
VENTRICULAR TACHYCARDIA5
VASCULAR GRAFT5
URINE CYTOLOGY ABNORMAL5
Treatment failure5
THROAT TIGHTNESS5
THERAPY NON-RESPONDER5
SUPRAVENTRICULAR TACHYCARDIA5
SUPRAVENTRICULAR EXTRASYSTOLES5
SPLENOMEGALY5
SOMNOLENCE5
SMALL INTESTINAL OBSTRUCTION5
SINUSITIS5
SCROTAL OEDEMA5
ROTATOR CUFF SYNDROME5
RETCHING5
RESPIRATORY DISORDER5
Respiratory arrest5
PULMONARY FIBROSIS5
Psychomotor skills impaired5
PROTHROMBIN TIME PROLONGED5
PHARYNGOLARYNGEAL PAIN5
PEMPHIGOID5
PANCREATITIS CHRONIC5
OBESITY5
NECK PAIN5
MUSCULOSKELETAL STIFFNESS5
METASTASES TO CENTRAL NERVOUS SYSTEM5
LUNG NEOPLASM5
LUNG INFILTRATION5
LUNG CANCER METASTATIC5
LOWER LIMB FRACTURE5
Limb discomfort5
JOINT DISLOCATION5
Jaundice cholestatic5
INTERVERTEBRAL DISC PROTRUSION5
Internal haemorrhage5
INTERCEPTED MEDICATION ERROR5
INJURY5
INCREASED APPETITE5
HYPERTENSIVE CRISIS5
HUMERUS FRACTURE5
HEPATOCELLULAR DAMAGE5
HEPATIC FUNCTION ABNORMAL5
HEAD INJURY5
HAEMOPTYSIS5
GASTRITIS5
GASTRIC ULCER5
GASTRIC DISORDER5
FLANK PAIN5
FAECES DISCOLOURED5
EYE DISORDER5
EXERCISE TOLERANCE DECREASED5
ESCHERICHIA URINARY TRACT INFECTION5
ELECTROCARDIOGRAM ST-T CHANGE5
DRUG INTOLERANCE5
Drug abuse5
DILATATION ATRIAL5
DIABETIC RETINAL OEDEMA5
CYSTITIS NONINFECTIVE5
Contraindicated product prescribed5
CEREBRAL HAEMORRHAGE5
Campylobacter gastroenteritis5
BLOOD MAGNESIUM DECREASED5
BLOOD LACTATE DEHYDROGENASE INCREASED5
BLOOD GLUCOSE FLUCTUATION5
BLOOD GLUCOSE ABNORMAL5
BLOOD ALBUMIN DECREASED5
BLADDER TRANSITIONAL CELL CARCINOMA RECURRENT5
ARTERIOSCLEROSIS5
ANURIA5
ANAPHYLACTIC REACTION5
ALOPECIA5
ACUTE CORONARY SYNDROME5
WRIST FRACTURE4
WHITE BLOOD CELL COUNT INCREASED4
URINARY BLADDER POLYP4
UNEVALUABLE EVENT4
ULNA FRACTURE4
Therapy cessation4
STRESS FRACTURE4
SPINAL OSTEOARTHRITIS4
SLEEP APNOEA SYNDROME4
Skin exfoliation4
SKIN DISCOLOURATION4
SKIN CANCER4
RHINORRHOEA4
RETINAL DETACHMENT4
RENAL NEOPLASM4
RECTAL HAEMORRHAGE4
RASH PRURITIC4
RALES4
PROTEINURIA4
PROTEIN URINE PRESENT4
PROSTATIC SPECIFIC ANTIGEN INCREASED4
Product use in unapproved indication4
PNEUMONIA ASPIRATION4
PATHOLOGICAL FRACTURE4
OCCULT BLOOD POSITIVE4
NORMOCHROMIC NORMOCYTIC ANAEMIA4
NO THERAPEUTIC RESPONSE4
NEPHROTIC SYNDROME4
NEOPLASM RECURRENCE4
MYOPATHY4
MOVEMENT DISORDER4
METASTASIS4
METASTASES TO URINARY TRACT4
METASTASES TO PROSTATE4
Medication monitoring error4
MACULOPATHY4
LYMPHOMA4
LUNG DISORDER4
Lower respiratory tract infection4
LOCALISED INFECTION4
LIP SWELLING4
LEFT VENTRICULAR FAILURE4
LACUNAR INFARCTION4
KNEE ARTHROPLASTY4
ISCHAEMIA4
INTESTINAL OBSTRUCTION4
INFECTIOUS MONONUCLEOSIS4
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION4
HYSTERECTOMY4
HYPOTHYROIDISM4
HYPERAESTHESIA4
HEPATITIS FULMINANT4
HEPATITIS C4
HEPATITIS ACUTE4
HEPATIC NEOPLASM MALIGNANT4
HEART RATE DECREASED4
Heart injury4
HAEMODIALYSIS4
GLUCOSE URINE PRESENT4
GALLBLADDER DISORDER4
Full blood count decreased4
FIBRIN D DIMER INCREASED4
EXOSTOSIS4
EPISTAXIS4
DYSPHAGIA4
DRUG ADMINISTRATION ERROR4
DIVERTICULITIS4
CARPAL TUNNEL SYNDROME4
CARDIAC TAMPONADE4
CARDIAC MURMUR4
CARDIAC FLUTTER4
BURNING SENSATION4
BUNDLE BRANCH BLOCK RIGHT4
BONE DENSITY DECREASED4
BLOOD URIC ACID INCREASED4
BLOOD IRON DECREASED4
BLOOD CHOLESTEROL INCREASED4
BLADDER TRANSITIONAL CELL CARCINOMA STAGE 04
Bladder cancer stage IV4
BACK INJURY4
AZOTAEMIA4
AUTOIMMUNE HEPATITIS4
ASTHMA4
ARTERIAL OCCLUSIVE DISEASE4
AORTIC VALVE INCOMPETENCE4
ANEURYSM4
AMNESIA4
ADENOCARCINOMA PANCREAS4
ACUTE MYELOID LEUKAEMIA4
ACTIVITIES OF DAILY LIVING IMPAIRED4
Abnormal loss of weight4
WRONG DRUG ADMINISTERED3
WEIGHT FLUCTUATION3
VITREOUS DETACHMENT3
VIRAL INFECTION3
VIITH NERVE PARALYSIS3
VENTRICULAR FIBRILLATION3
VENTRICULAR DYSFUNCTION3
Varicella3
URINE OUTPUT DECREASED3
URINE ABNORMALITY3
Urinary tract disorder3
Tumour pain3
TROPONIN INCREASED3
Traumatic lung injury3
TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER3
Toxicity to various agents3
TOOTH FRACTURE3
TOOTH ABSCESS3
THROAT IRRITATION3
Throat cancer3
Therapeutic response decreased3
SURGERY3
SUBARACHNOID HAEMORRHAGE3
STRESS3
STENT PLACEMENT3
STAPHYLOCOCCAL INFECTION3
SQUAMOUS CELL CARCINOMA3
SLEEP DISORDER3
SKULL FRACTURE3
Skin lesion3
SHOCK HAEMORRHAGIC3
Sexual dysfunction3
SELF-MEDICATION3
SCHIZOPHRENIA3
Scapula fracture3
RETINAL OEDEMA3
RETINAL NEOVASCULARISATION3
RETINAL DISORDER3
RED BLOOD CELL SEDIMENTATION RATE INCREASED3
RASH GENERALISED3
PYURIA3
PURULENCE3
PUBIS FRACTURE3
PROSTATITIS3
Product use issue3
Product dispensing error3
POSTOPERATIVE WOUND INFECTION3
POST PROCEDURAL HAEMORRHAGE3
Pneumothorax traumatic3
PNEUMONITIS3
Plasma cell myeloma3
PHOTOSENSITIVITY REACTION3
PHOTOPHOBIA3
PHARYNGITIS3
PHARYNGEAL OEDEMA3
Perirectal abscess3
PERIPHERAL VASCULAR DISORDER3
PERIPHERAL ARTERIAL OCCLUSIVE DISEASE3
PELVIC PAIN3
PELVIC MASS3
PELVIC FRACTURE3
PARAESTHESIA ORAL3
PAPILLOEDEMA3
PANCREATIC DISORDER3
Palmar-plantar erythrodysaesthesia syndrome3
OSTEONECROSIS3
NASAL CONGESTION3
N-terminal prohormone brain natriuretic peptide increased3
MYOSITIS3
MUSCLE NECROSIS3
MULTIPLE SCLEROSIS3
Metabolic disorder3
MATERNAL EXPOSURE DURING PREGNANCY3
MALIGNANT NEOPLASM PROGRESSION3
Malignant neoplasm of unknown primary site3
LYMPHOEDEMA3
LOW DENSITY LIPOPROTEIN INCREASED3
Liver injury3
LIPOMA3
LIPASE INCREASED3
LARGE INTESTINE CARCINOMA3
Kidney enlargement3
JUGULAR VEIN DISTENSION3
JOINT SPRAIN3
JOINT EFFUSION3
IRRITABILITY3
INTERVERTEBRAL DISC DEGENERATION3
INTERMITTENT CLAUDICATION3
INTERCEPTED DRUG DISPENSING ERROR3
INFLUENZA LIKE ILLNESS3
Inappropriate schedule of product administration3
INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION3
IMPAIRED HEALING3
IMPAIRED DRIVING ABILITY3
HYPOPHAGIA3
Hypomagnesaemia3
HYPOCHROMIC ANAEMIA3
HYPERPHAGIA3
HYPERLIPIDAEMIA3
HYPERKERATOSIS3
HUNGER3
HIP ARTHROPLASTY3
HIATUS HERNIA3
HERNIA3
HEPATIC NECROSIS3
HEPATIC CANCER METASTATIC3
Hepatic cancer3
HEMIPARESIS3
HAEMORRHAGIC STROKE3
HAEMORRHAGE URINARY TRACT3
HAEMATOCHEZIA3
HAEMATEMESIS3
GROIN PAIN3
GRAND MAL CONVULSION3
GOUT3
GOITRE3
GINGIVAL PAIN3
GASTROOESOPHAGEAL REFLUX DISEASE3
Gait inability3
Feeding disorder3
FAILURE TO THRIVE3
FACIAL BONES FRACTURE3
EYE SWELLING3
EXTRASYSTOLES3
ESCHERICHIA INFECTION3
Erysipelas3
ERUCTATION3
EPIGASTRIC DISCOMFORT3
EOSINOPHILIA3
EMPHYSEMA3
ECZEMA3
DYSSTASIA3
DYSPNOEA PAROXYSMAL NOCTURNAL3
DYSLIPIDAEMIA3
DYSKINESIA3
DYSGEUSIA3
DYSARTHRIA3
DRY EYE3
Drug-induced liver injury3
DRUG TOXICITY3
DIVERTICULUM3
DISEASE PROGRESSION3
DIASTOLIC DYSFUNCTION3
DEMENTIA ALZHEIMER'S TYPE3
CYSTITIS HAEMORRHAGIC3
COLONIC POLYP3
COLD SWEAT3
COAGULOPATHY3
Clavicle fracture3
Chronic kidney disease3
CHOLECYSTITIS ACUTE3
Cervix carcinoma3
Cell marker increased3
CATHETERISATION CARDIAC3
CAROTID ARTERY OCCLUSION3
CAESAREAN SECTION3
BRAIN STEM INFARCTION3
Bone cancer3
BLOOD LACTIC ACID INCREASED3
Blood electrolytes abnormal3
BLOOD CREATINE INCREASED3
BLOOD AMYLASE INCREASED3
BLOOD ALBUMIN INCREASED3
Bladder transitional cell carcinoma stage IV3
Bladder transitional cell carcinoma metastatic3
Bladder pain3
BLADDER DYSPLASIA3
BEDRIDDEN3
ATRIOVENTRICULAR BLOCK3
ASPIRATION3
ARTHROPATHY3
APNOEA3
AORTIC ANEURYSM3
ANGIOPATHY3
ANAEMIA POSTOPERATIVE3
AGGRESSION3
Adult failure to thrive3
ADRENAL NEOPLASM3
ADENOCARCINOMA3
ACUTE RESPIRATORY DISTRESS SYNDROME3
ACCIDENTAL EXPOSURE3
ABNORMAL BEHAVIOUR3
ABDOMINAL HERNIA3
WRONG TECHNIQUE IN DRUG USAGE PROCESS2
WOUND INFECTION2
WEIGHT LOSS POOR2
Vitreous adhesions2
VITAMIN B12 DEFICIENCY2
VASCULAR OCCLUSION2
VASCULAR CALCIFICATION2
VARICES OESOPHAGEAL2
Urogenital infection fungal2
URINE ODOUR ABNORMAL2
Urinary tract obstruction2
Urinary bladder haemorrhage2
Ureteral neoplasm2
UPPER RESPIRATORY TRACT INFLAMMATION2
Unresponsive to stimuli2
UMBILICAL HERNIA2
ULCER2
TYPE 1 DIABETES MELLITUS2
TRICHOMONIASIS2
Traumatic intracranial haemorrhage2
TOOTHACHE2
TOOTH LOSS2
TOE DEFORMITY2
TOE AMPUTATION2
THYROID NEOPLASM2
THERAPEUTIC RESPONSE UNEXPECTED2
Therapeutic product effect decreased2
THERAPEUTIC PRODUCT CONTAMINATION2
TENSION HEADACHE2
TENDONITIS2
TENDON RUPTURE2
SUICIDAL IDEATION2
SUDDEN CARDIAC DEATH2
SUBDURAL HAEMATOMA2
STRESS URINARY INCONTINENCE2
Stomatitis2
STOMACH DISCOMFORT2
STEVENS-JOHNSON SYNDROME2
SPINAL COLUMN STENOSIS2
Somnambulism2
Small intestine carcinoma2
SMALL INTESTINAL HAEMORRHAGE2
SLUGGISHNESS2
Skin swelling2
SKIN IRRITATION2
SKIN HYPERPIGMENTATION2
Skin fragility2
Skin burning sensation2
SHOULDER PAIN2
SENSORY DISTURBANCE2
SENSITIVITY OF TEETH2
SARCOMA2
SALPINGO-OOPHORECTOMY BILATERAL2
RHINITIS ALLERGIC2
RHINITIS2
RETINOPATHY2
RETINAL ISCHAEMIA2
Retinal degeneration2
RESPIRATORY RATE INCREASED2
Respiratory alkalosis2
RENAL CELL CARCINOMA STAGE UNSPECIFIED2
RENAL ATROPHY2
QRS AXIS ABNORMAL2
Pyelonephritis2
PURPURA2
PRURITUS GENERALISED2
PROSTATOMEGALY2
PROSTATIC OBSTRUCTION2
PRODUCT QUALITY ISSUE2
Product prescribing error2
Product physical issue2
PRECANCEROUS CELLS PRESENT2
Poverty of speech2
POLYMYALGIA RHEUMATICA2
PO2 DECREASED2
PNEUMOTHORAX2
Platelet adhesiveness2
PITUITARY TUMOUR BENIGN2
PICKWICKIAN SYNDROME2
Physical deconditioning2
Periprosthetic fracture2
PERIPHERAL COLDNESS2
PERIORBITAL OEDEMA2
PENILE OEDEMA2
PANCREATIC CYST2
OXYGEN SATURATION DECREASED2
OSTEOMYELITIS2
OCULAR ICTERUS2
NON-CARDIAC CHEST PAIN2
NO ADVERSE REACTION2
NO ADVERSE EFFECT2
NEUROPATHIC ARTHROPATHY2
NERVE INJURY2
Nephropathy2
NEPHROGENIC ANAEMIA2
NEPHRITIS INTERSTITIAL2
NEPHRITIS ALLERGIC2
NEOPLASM PROGRESSION2
MYELODYSPLASTIC SYNDROME2
MUSCLE ATROPHY2
Multiple organ dysfunction syndrome2
MONOPARESIS2
MITRAL VALVE SCLEROSIS2
Middle insomnia2
Micturition disorder2
METASTATIC NEOPLASM2
Metastases to spine2
Metastases to reproductive organ2
Metastases to pancreas2
METASTASES TO ADRENALS2
MENTAL DISORDER2
MENISCUS LESION2
MELAENA2
MEDIASTINAL MASS2
Macular fibrosis2
LUNG ADENOCARCINOMA2
LUMBAR SPINAL STENOSIS2
LOSS OF EMPLOYMENT2
Loss of control of legs2
Liver function test increased2
Lipodystrophy acquired2
Lip neoplasm malignant stage unspecified2
LEUKOCYTOSIS2
LEG AMPUTATION2
Laryngeal oedema2
Large intestinal haemorrhage2
LABORATORY TEST ABNORMAL2
KETOACIDOSIS2
JOINT RANGE OF MOTION DECREASED2
JOINT INJURY2
ISCHAEMIC STROKE2
INTESTINAL PERFORATION2
INTERVERTEBRAL DISC DISORDER2
Intentional self-injury2
Intentional product misuse2
Inguinal hernia2
Influenza A virus test positive2
ILL-DEFINED DISORDER2
HYPOGLYCAEMIC SEIZURE2
HYPOGLYCAEMIC ENCEPHALOPATHY2
HYPOGLYCAEMIA NEONATAL2
HYPOACUSIS2
HYPERCALCAEMIA2
HYPERAMMONAEMIA2
HYDROCEPHALUS2
HEPATOMEGALY2
HEPATITIS TOXIC2
HEPATITIS B2
HEPATIC HAEMATOMA2
Hepatic enzyme abnormal2
HEMIPLEGIA2
HEART RATE IRREGULAR2
HEART DISEASE CONGENITAL2
HAEMORRHOIDS2
HAEMOLYTIC ANAEMIA2
GLOMERULAR FILTRATION RATE DECREASED2
Genital infection fungal2
Gastroenteritis2
Fungal infection2
FRACTURED COCCYX2
Foot amputation2
Foetal exposure during pregnancy2
FEELING HOT2
FEELING COLD2
FAT TISSUE INCREASED2
FACIAL PALSY2
EYELID OEDEMA2
EXCORIATION2
ESSENTIAL HYPERTENSION2
ERYTHEMA MULTIFORME2
Epilepsy2
ENTEROCOCCAL INFECTION2
ENDOMETRIAL CANCER2
ELECTROCARDIOGRAM T WAVE INVERSION2
ELECTROCARDIOGRAM T WAVE AMPLITUDE DECREASED2
ELECTROCARDIOGRAM ST SEGMENT ELEVATION2
ELECTROCARDIOGRAM ST SEGMENT ABNORMAL2
ELECTROCARDIOGRAM ABNORMAL2
EAR PAIN2
EAR INFECTION2
DYSPNOEA EXACERBATED2
DYSPHONIA2
DUODENAL ULCER2
Dry skin2
Dry mouth2
DIVERTICULUM INTESTINAL2
Disorientation2
DIPLOPIA2
DILATATION VENTRICULAR2
DIABETIC COMPLICATION2
DIABETES MELLITUS INSULIN-DEPENDENT2
Dermatitis2
DENTAL CARIES2
DEMENTIA2
Cutaneous symptom2
CRUSH INJURY2
Coordination abnormal2
CONGESTIVE CARDIOMYOPATHY2
COLITIS ULCERATIVE2
COGNITIVE DISORDER2
Clear cell renal cell carcinoma2
CHOLESTASIS2
CHOLECYSTITIS2
CHOLECYSTECTOMY2
CHOLANGITIS2
CHOKING2
CEREBRAL HAEMATOMA2
Cells in urine2
CATARACT OPERATION2
CATARACT NUCLEAR2
CARDIAC VALVE DISEASE2
CANDIDIASIS2
CALCULUS URINARY2
BUNDLE BRANCH BLOCK LEFT2
BRONCHOSPASM2
BONE CANCER METASTATIC2
BODY HEIGHT DECREASED2
BLOOD URINE2
BLOOD THYROID STIMULATING HORMONE INCREASED2
Blood thyroid stimulating hormone decreased2
BLOOD TEST ABNORMAL2
BLOOD IMMUNOGLOBULIN G INCREASED2
BLOOD IMMUNOGLOBULIN E INCREASED2
Blood calcium increased2
BLOOD CALCIUM DECREASED2
BLADDER SQUAMOUS CELL CARCINOMA STAGE UNSPECIFIED2
Bladder injury2
BLADDER HYPERTROPHY2
BIPOLAR DISORDER2
BILIRUBIN CONJUGATED INCREASED2
BILE DUCT OBSTRUCTION2
BILE DUCT CANCER2
Benign neoplasm of bladder2
BACTERIA URINE2
Autonomic nervous system imbalance2
ATRIOVENTRICULAR BLOCK SECOND DEGREE2
ARTERIOSCLEROSIS CORONARY ARTERY2
Aortitis2
AORTIC VALVE SCLEROSIS2
AORTIC ATHEROSCLEROSIS2
ANGIONEUROTIC OEDEMA2
ANAEMIA VITAMIN B12 DEFICIENCY2
Allergic reaction to excipient2
ALCOHOLIC LIVER DISEASE2
ALCOHOL USE2
ALBUMINURIA2
ALBUMIN URINE PRESENT2
ADRENAL ADENOMA2
ADHESION2
Acute lung injury2
ACIDOSIS2
ACCIDENTAL OVERDOSE2
ACCIDENT2
ABSCESS2
ABDOMINAL ADHESIONS2
YELLOW SKIN1
Wrong technique in product usage process1
WOUND SECRETION1
WOUND1
Withdrawal syndrome1
WHITE BLOOD CELLS URINE POSITIVE1
WHITE BLOOD CELLS URINE1
WHEELCHAIR USER1
Weight bearing difficulty1
Weight abnormal1
WEGENER'S GRANULOMATOSIS1
WAIST CIRCUMFERENCE INCREASED1
Vulvovaginitis trichomonal1
Vulvovaginal discomfort1
Vulval cancer1
VITREOUS FLOATERS1
VITAMIN D DEFICIENCY1
VITAMIN D DECREASED1
VITAMIN B12 DECREASED1
Vestibular disorder1
VERTEBRAL FORAMINAL STENOSIS1
Ventricular hypoplasia1
VENTRICULAR HYPOKINESIA1
VENOUS OCCLUSION1
VENOUS INSUFFICIENCY1
VEIN DISORDER1
Vasculitis1
VASCULAR GRAFT OCCLUSION1
VASCULAR ANOMALY1
Vaginal infection1
VAGINAL HAEMORRHAGE1
VAGINAL CANCER1
UTERINE LEIOMYOMA1
Uterine haemorrhage1
Uterine contractions abnormal1
UTERINE CANCER1
URINE KETONE BODY PRESENT1
URINE COLOUR ABNORMAL1
Urine alkalinisation therapy1
URINARY TRACT NEOPLASM1
Urinary bladder rupture1
URETHRAL STENOSIS1
URETHRAL PAPILLOMA1
Ureterolithiasis1
Ureteric obstruction1
URETERIC CANCER METASTATIC1
URETERIC CANCER LOCAL1
Ureteral disorder1
UPPER RESPIRATORY TRACT INFECTION1
UPPER RESPIRATORY TRACT CONGESTION1
Upper gastrointestinal haemorrhage1
UNRESPONSIVE TO VERBAL STIMULI1
UNDERDOSE1
Type 2 diabetes mellitus1
TUMOUR NECROSIS1
TUMOUR INVASION1
TUMOUR HAEMORRHAGE1
TUBERCULIN TEST POSITIVE1
TROPONIN T INCREASED1
TRISOMY 211
Traumatic fracture1
Transitional cell carcinoma urethra1
TRANSITIONAL CELL CARCINOMA METASTATIC1
TRANSFERRIN SATURATION DECREASED1
TRACHEAL STENOSIS1
TRACHEAL DEVIATION1
Tracheal cancer1
TOXIC INDUCED ENCEPHALOPATHY1
TOXIC EPIDERMAL NECROLYSIS1
TOOTH INFECTION1
Tonsil cancer1
TONGUE PARALYSIS1
Tinnitus1
THYROID DISORDER1
THYROID CYST1
THYROID CANCER1
THYROID ADENOMA1
THROMBOCYTOPENIC PURPURA1
THROMBIN-ANTITHROMBIN III COMPLEX INCREASED1
Threatened labour1
THINKING ABNORMAL1
Thermal burn1
Therapy interrupted1
THERAPEUTIC PRODUCT INEFFECTIVE1
Therapeutic product effect incomplete1
THERAPEUTIC AGENT TOXICITY1
TESTICULAR PAIN1
TENSION1
Temporomandibular joint syndrome1
TEMPERATURE INTOLERANCE1
TEETH BRITTLE1
Taste disorder1
T-CELL LYMPHOMA1
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME1
Swelling of eyelid1
SURGICAL PROCEDURE REPEATED1
Substance abuse1
SUBRETINAL FIBROSIS1
Subcutaneous abscess1
STUPOR1
STRESS SYMPTOMS1
STRESS CARDIOMYOPATHY1
STREPTOCOCCAL URINARY TRACT INFECTION1
Status epilepticus1
STATUS ASTHMATICUS1
SPUTUM DISCOLOURED1
SPONDYLOLISTHESIS1
Spondylitis1
SPLENIC INFARCTION1
Spinal ligament ossification1
Spinal fusion surgery1
SPINAL DEFORMITY1
Spinal cord neoplasm1
Soft tissue mass1
SODIUM RETENTION1
Small intestine adenocarcinoma1
SKIN LACERATION1
Skin infection1
SKIN HYPERTROPHY1
SINUS HEADACHE1
SINUS DISORDER1
Silent myocardial infarction1
Sideroblastic anaemia1
SICK SINUS SYNDROME1
SERUM FERRITIN INCREASED1
SERUM FERRITIN DECREASED1
SENSORY LOSS1
SELF-INJURIOUS IDEATION1
SELF-INDUCED VOMITING1
Seizure like phenomena1
Seizure1
SECRETION DISCHARGE1
SCOLIOSIS1
SCLERITIS1
SCHIZOPHRENIFORM DISORDER1
SCAR1
SARCOMA METASTATIC1
SALPINGO-OOPHORITIS1
RUPTURED CEREBRAL ANEURYSM1
RIGHT VENTRICULAR SYSTOLIC PRESSURE INCREASED1
RETROPERITONEAL FIBROSIS1
RETINAL VASCULAR DISORDER1
RETINAL PIGMENT EPITHELIOPATHY1
RETINAL ARTERY OCCLUSION1
RETINAL ARTERY EMBOLISM1
RESTLESS LEGS SYNDROME1
RESPIRATORY DISTRESS1
Respiratory depression1
RENAL TUBULAR ACIDOSIS1
RENAL TRANSPLANT1
RENAL PAIN1
Renal injury1
RENAL HAEMORRHAGE1
Renal embolism1
RENAL CELL CARCINOMA STAGE II1
Renal cancer metastatic1
REFUSAL OF TREATMENT BY RELATIVE1
REFLUX OESOPHAGITIS1
RED BLOOD CELLS URINE POSITIVE1
RED BLOOD CELL ELLIPTOCYTES PRESENT1
RED BLOOD CELL COUNT INCREASED1
RED BLOOD CELL COUNT DECREASED1
Rectal ulcer1
Rectal adenocarcinoma1
REACTION TO DRUG EXCIPIENTS1
RASH VESICULAR1
Rash maculo-papular1
RASH MACULAR1
Rash erythematous1
Radiation skin injury1
RADIATION INJURY1
QUADRIPARESIS1
Pyelonephritis acute1
PURULENT DISCHARGE1
Pulseless electrical activity1
PULSE ABNORMAL1
PULMONARY VASCULAR DISORDER1
PULMONARY VALVE INCOMPETENCE1
Pulmonary toxicity1
PULMONARY THROMBOSIS1
PULMONARY INFARCTION1
Pulmonary alveolar haemorrhage1
PUBIC RAMI FRACTURE1
PTERYGIUM1
Psychomotor retardation1
PSORIASIS1
PROTHROMBIN LEVEL INCREASED1
PROTEIN TOTAL INCREASED1
PROTEIN TOTAL DECREASED1
Prostatic disorder1
PROSTATIC CALCIFICATION1
PROSTATE EXAMINATION ABNORMAL1
PROSTATE CANCER STAGE II1
PROSTATE CANCER METASTATIC1
Product packaging confusion1
Product formulation issue1
PROCEDURAL SITE REACTION1
Presyncope1
PREMATURE LABOUR1
PREGNANCY WITH CONTRACEPTIVE DEVICE1
PRECANCEROUS SKIN LESION1
POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME1
POSTRENAL FAILURE1
POSTPARTUM HAEMORRHAGE1
POSTOPERATIVE ABSCESS1
POSTNASAL DRIP1
POST PROCEDURAL PAIN1
POST HERPETIC NEURALGIA1
PORTAL VEIN PHLEBITIS1
PORTAL HYPERTENSION1
POOR QUALITY DRUG ADMINISTERED1
POOR PERIPHERAL CIRCULATION1
Polyp1
POLYNEUROPATHY1
POLYARTHRITIS1
PNEUMONIA VIRAL1
PNEUMONIA PRIMARY ATYPICAL1
PNEUMONIA MYCOPLASMAL1
PNEUMATURIA1
PLEURITIC PAIN1
PLEURISY1
PLEURAL FIBROSIS1
PLATELET DESTRUCTION INCREASED1
PLATELET COUNT INCREASED1
PLANTAR FASCIITIS1
PLACENTAL INSUFFICIENCY1
PHYSICAL ABUSE1
PHIMOSIS1
Pharyngeal swelling1
PHARYNGEAL ERYTHEMA1
PHAEOCHROMOCYTOMA1
Peyronie's disease1
PETECHIAE1
PERSONALITY CHANGE1
PERSECUTORY DELUSION1
PERITONITIS1
PERIPHERAL SENSORIMOTOR NEUROPATHY1
Peripheral revascularisation1
PERICARDIAL DRAINAGE1
PERIARTHRITIS1
PENIS DISORDER1
Penile pain1
Penile haemorrhage1
Penile abscess1
PELVIC NEOPLASM1
PEAU D'ORANGE1
PATELLA FRACTURE1
PARALYSIS1
Papilloma1
Papillary thyroid cancer1
PANIC DISORDER1
Panic attack1
PANCREATITIS RELAPSING1
PANCREATIC NECROSIS1
PANCREATIC MASS1
PANCREATIC LEAK1
PANCREATIC DUCT OBSTRUCTION1
Pancreatic carcinoma stage III1
PANCREATECTOMY1
PANCREAS INFECTION1
PALLOR1
PAINFUL DEFAECATION1
PAIN IN JAW1
OVARIAN NEOPLASM1
OVARIAN GERM CELL TERATOMA BENIGN1
Otorrhoea1
Otitis externa1
OSTEOLYSIS1
Oropharyngeal cancer1
ORAL INTAKE REDUCED1
OPTIC NEURITIS1
OPTIC ATROPHY1
OPEN WOUND1
OESOPHAGOGASTRIC FUNDOPLASTY1
OESOPHAGEAL VARICES HAEMORRHAGE1
OESOPHAGEAL STENOSIS1
Oesophageal carcinoma1
OESOPHAGEAL CANDIDIASIS1
OEDEMA GENITAL1
Occupational problem environmental1
OCCULT BLOOD1
OBSTRUCTIVE AIRWAYS DISORDER1
NYSTAGMUS1
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL1
Normal newborn1
Non-small cell lung cancer metastatic1
NOCTURNAL DYSPNOEA1
NEUTROPHIL PERCENTAGE INCREASED1
NEUTROPHIL COUNT DECREASED1
NEUROLEPTIC MALIGNANT SYNDROME1
NEUROGLYCOPENIA1
Neuroendocrine carcinoma metastatic1
NEUROENDOCRINE CARCINOMA1
NERVOUS SYSTEM DISORDER1
NEPHROPATHY TOXIC1
NEOVASCULARISATION1
NEONATAL HYPOXIA1
NECROTISING COLITIS1
NECROSIS1
NECK INJURY1
NASOPHARYNGEAL DISORDER1
NASAL SEPTUM DEVIATION1
MYOCLONUS1
MYELOID LEUKAEMIA1
MYCOPLASMA SEROLOGY POSITIVE1
MYCOBACTERIUM AVIUM COMPLEX INFECTION1
MUSCULOSKELETAL CHEST PAIN1
MUSCLE TWITCHING1
MUSCLE TIGHTNESS1
MUSCLE STRAIN1
MUSCLE OEDEMA1
MUSCLE INJURY1
MUSCLE HAEMORRHAGE1
MUSCLE DISORDER1
MULTIPLE FRACTURES1
MULTIPLE ALLERGIES1
MULTI-ORGAN FAILURE1
MUCOUS STOOLS1
MUCOUS MEMBRANE DISORDER1
Mucosal inflammation1
MONOCYTE COUNT INCREASED1
MONOCYTE COUNT DECREASED1
MIXED RECEPTIVE-EXPRESSIVE LANGUAGE DISORDER1
MIXED HYPERLIPIDAEMIA1
MITRAL VALVE PROLAPSE1
MITRAL VALVE DISEASE1
MICROCYTIC ANAEMIA1
Metastatic renal cell carcinoma1
METASTATIC GASTRIC CANCER1
METASTASES TO SKIN1
Metastases to retroperitoneum1
Metastases to rectum1
METASTASES TO PERITONEUM1
Metastases to peripheral vascular system1
METASTASES TO NERVOUS SYSTEM1
METASTASES TO MUSCLE1
METAPNEUMOVIRUS INFECTION1
Menstruation irregular1
MENORRHAGIA1
MENOPAUSAL SYMPTOMS1
Meniscus injury1
MENINGORRHAGIA1
MEAN CELL HAEMOGLOBIN INCREASED1
MANTLE CELL LYMPHOMA STAGE IV1
MALNUTRITION1
MALLORY-WEISS SYNDROME1
MALIGNANT URINARY TRACT NEOPLASM1
Malignant spinal cord compression1
Malignant nipple neoplasm female1
MALIGNANT MELANOMA1
MACULAR SCAR1
MACULAR PSEUDOHOLE1
MACULAR DEGENERATION1
Lymphopenia1
LYMPHOID TISSUE HYPERPLASIA1
LYMPHOCYTE PERCENTAGE DECREASED1
LYMPHADENOPATHY MEDIASTINAL1
LUNG CONSOLIDATION1
LUNG CARCINOMA CELL TYPE UNSPECIFIED STAGE IV1
Lung adenocarcinoma metastatic1
LUMBAR RADICULOPATHY1
LOWER LIMB DEFORMITY1
Lower gastrointestinal haemorrhage1
LOSS OF LIBIDO1
LOGORRHOEA1
LOBAR PNEUMONIA1
LIVER TRANSPLANT1
LIVER TENDERNESS1
LIVER FUNCTION TEST1
LIPOMATOSIS1
LIPOGRANULOMA1
LIPIDS INCREASED1
Lip infection1
LIMB INJURY1
LIGAMENT SPRAIN1
LIFE SUPPORT1
Libido decreased1
LEUKOCYTOCLASTIC VASCULITIS1
Leukaemia1
LEUCINE AMINOPEPTIDASE INCREASED1
Lens disorder1
LEIOMYOMA1
LEFT ATRIAL DILATATION1
Large intestine perforation1
LARGE INTESTINAL ULCER1
Large intestinal obstruction1
Lacrimation increased1
LACERATION1
KYPHOSIS1
Klebsiella infection1
Kidney fibrosis1
KETOSIS1
JOINT STIFFNESS1
IRON DEFICIENCY1
INTUBATION1
INTRAOCULAR PRESSURE INCREASED1
INTESTINAL ISCHAEMIA1
INTERNATIONAL NORMALISED RATIO DECREASED1
INSULIN-LIKE GROWTH FACTOR DECREASED1
Insulin C-peptide increased1
INSULIN C-PEPTIDE DECREASED1
INJURY ASPHYXIATION1
INJECTION SITE PAIN1
INJECTION SITE MASS1
Injection site bruising1
INITIAL INSOMNIA1
Inflammatory bowel disease1
INFECTIOUS PERITONITIS1
INFECTION PARASITIC1
INFARCTION1
INDURATION1
INCREASED UPPER AIRWAY SECRETION1
INCISION SITE INFECTION1
INCISION SITE ABSCESS1
INADEQUATE ANALGESIA1
Impaired insulin secretion1
Immune system disorder1
ILIUM FRACTURE1
ILIOTIBIAL BAND SYNDROME1
Ileus paralytic1
Ileus1
ILEOSTOMY1
IDIOPATHIC THROMBOCYTOPENIC PURPURA1
IATROGENIC INJURY1
HYPOXIC-ISCHAEMIC ENCEPHALOPATHY1
Hypovolaemic shock1
HYPOVOLAEMIA1
Hypothermia1
HYPOPNOEA1
Hypophosphataemia1
Hypokinesia1
HYPOCHLORAEMIA1
HYPOALBUMINAEMIA1
HYPOAESTHESIA ORAL1
HYPO HDL CHOLESTEROLAEMIA1
HYPERVENTILATION1
HYPERTROPHIC CARDIOMYOPATHY1
Hyperthermia malignant1
HYPERTENSIVE NEPHROPATHY1
HYPERTENSIVE HEART DISEASE1
HYPERTENSIVE CARDIOMYOPATHY1
HYPERSOMNIA1
HYPERREFLEXIA1
Hyperlactacidaemia1
Hypergammaglobulinaemia benign monoclonal1
HYPERGAMMAGLOBULINAEMIA1
HYPERCHOLESTEROLAEMIA1
HYPERBILIRUBINAEMIA1
HYPERADRENALISM1
HOT FLUSH1
HIP SWELLING1
Hip surgery1
HIGH DENSITY LIPOPROTEIN DECREASED1
HERNIA OBSTRUCTIVE1
HEPATORENAL SYNDROME1
HEPATOCELLULAR INJURY1
Hepatocellular carcinoma1
HEPATITIS INFECTIOUS1
HEPATITIS CHOLESTATIC1
HEPATITIS C ANTIBODY POSITIVE1
HEPATITIS A POSITIVE1
HEPATITIS A1
HEPATIC PAIN1
HEPATIC MASS1
HEPATIC INFECTION1
HEPATIC INFARCTION1
HEPATIC FIBROSIS1
HEPATIC ENCEPHALOPATHY1
HEPATIC CYST1
HEPATIC CANCER STAGE IV1
HEPATIC ATROPHY1
HEMIANOPIA HOMONYMOUS1
HELICOBACTER PYLORI IDENTIFICATION TEST POSITIVE1
HELICOBACTER INFECTION1
HELICOBACTER GASTRITIS1
Heart valve replacement1
Heart valve incompetence1
HEAD TITUBATION1
Head discomfort1
Hallucination, visual1
HAEMORRHOID OPERATION1
HAEMORRHAGE SUBCUTANEOUS1
HAEMORRHAGE INTRACRANIAL1
HAEMOLYSIS1
HAEMOGLOBIN INCREASED1
HAEMATOCRIT INCREASED1
Haematinuria1
HAEMANGIOMA OF LIVER1
Haemangioma of bone1
GROWTH HORMONE DEFICIENCY1
GRIP STRENGTH DECREASED1
GREENSTICK FRACTURE1
Gravitational oedema1
GRANULOMA ANNULARE1
Granulocyte count increased1
GOUTY ARTHRITIS1
Glycosuria1
GLUCOSE URINE1
GLOSSODYNIA1
GLOMERULOSCLEROSIS1
GLOMERULONEPHRITIS PROLIFERATIVE1
GINGIVAL ERYTHEMA1
GINGIVAL CYST1
GINGIVAL BLEEDING1
GINGIVAL ABSCESS1
Genotype drug resistance test positive1
Genitourinary tract neoplasm1
GENERALISED ERYTHEMA1
Gastrointestinal neoplasm1
GASTROINTESTINAL NECROSIS1
GASTROINTESTINAL MOTILITY DISORDER1
Gastrointestinal injury1
GASTROINTESTINAL EROSION1
Gastroenteritis viral1
GASTRODUODENAL HAEMORRHAGE1
GASTRITIS HAEMORRHAGIC1
GASTRITIS EROSIVE1
GASTRITIS ATROPHIC1
GASTRIC OPERATION1
GASTRIC HAEMORRHAGE1
GASTRIC BYPASS1
GASTRECTOMY1
GANGRENE1
GALLBLADDER OEDEMA1
GALLBLADDER ENLARGEMENT1
Gallbladder cancer1
Functional gastrointestinal disorder1
FREQUENT BOWEL MOVEMENTS1
Fractured sacrum1
Fournier's gangrene1
FOREARM FRACTURE1
FOOT DEFORMITY1
Food craving1
FOOD ALLERGY1
FOLATE DEFICIENCY1
FOETAL MALFORMATION1
FOETAL GROWTH RESTRICTION1
FLUSHING1
Fibromyalgia1
FEELING OF BODY TEMPERATURE CHANGE1
Fear of death1
Fasting1
FASCIITIS1
FALSE POSITIVE LABORATORY RESULT1
FAECAL OCCULT BLOOD POSITIVE1
FAECAL INCONTINENCE1
EYE PAIN1
Eye operation1
EYE OEDEMA1
EYE IRRIGATION1
EYE DISCHARGE1
EXTRAVASATION1
EXCITABILITY1
Euglycaemic diabetic ketoacidosis1
ESCHAR1
Erythema nodosum1
EOSINOPHILIC PNEUMONIA1
ENZYME ABNORMALITY1
ENTEROCOLITIS HAEMORRHAGIC1
Enlarged uvula1
Endolymphatic hydrops1
Endocarditis bacterial1
ENCEPHALOPATHY1
ENCEPHALITIS1
Emotional distress1
EMOTIONAL DISORDER1
ELECTROLYTE IMBALANCE1
ELECTROENCEPHALOGRAM ABNORMAL1
ELECTROCARDIOGRAM T WAVE ABNORMAL1
ELECTROCARDIOGRAM ST-T SEGMENT DEPRESSION1
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION1
ELECTROCARDIOGRAM QT CORRECTED INTERVAL SHORTENED1
ELECTROCARDIOGRAM QRS COMPLEX ABNORMAL1
ELECTROCARDIOGRAM Q WAVE ABNORMAL1
EFFUSION1
ECTOPIC PREGNANCY1
ECONOMIC PROBLEM1
ECCHYMOSIS1
Ear haemorrhage1
DYSPHEMIA1
DYSGRAPHIA1
DYSENTERY1
DYSACUSIS1
DUODENITIS1
DUODENAL ULCER PERFORATION1
DUODENAL POLYP1
DRY THROAT1
DRUG WITHDRAWAL SYNDROME1
Drug reaction with eosinophilia and systemic symptoms1
DRUG LEVEL DECREASED1
DRUG LEVEL BELOW THERAPEUTIC1
DRUG INTERACTION POTENTIATION1
DRUG DOSE OMISSION1
Distributive shock1
DISEASE COMPLICATION1
DISCOMFORT1
Disability1
DIPLEGIA1
DIARRHOEA INFECTIOUS1
Diabetic ulcer1
DIABETIC GANGRENE1
DIABETIC CARDIOMYOPATHY1
DIABETES INSIPIDUS1
DERMOGRAPHISM1
Dermatophytosis of nail1
DERMATITIS BULLOUS1
DEPRESSIVE SYMPTOM1
DEPRESSED MOOD1
Dentofacial anomaly1
DELUSION1
DEFAECATION URGENCY1
Deafness unilateral1
DEAFNESS1
CYTOMEGALOVIRUS INFECTION1
Cystoid macular oedema1
CYSTOCELE1
Cystitis klebsiella1
Cushing's syndrome1
CULTURE URINE POSITIVE1
Cryptorchism1
CRYPTOGENIC CIRRHOSIS1
Crying1
CROHN'S DISEASE1
CREPITATIONS1
CRACKLES LUNG1
CORONARY OSTIAL STENOSIS1
CORONARY ARTERY SURGERY1
CORONARY ARTERY RESTENOSIS1
CORONARY ARTERY BYPASS1
CORONARY ARTERIAL STENT INSERTION1
CORNEAL OEDEMA1
COR PULMONALE1
Contraindication to medical treatment1
Continuous haemodiafiltration1
CONGENITAL ANOMALY1
COMPUTERISED TOMOGRAM ABNORMAL1
COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS1
COMPLEX REGIONAL PAIN SYNDROME1
COLONIC STENOSIS1
COLONIC HAEMORRHAGE1
Colon cancer stage III1
COLON ADENOMA1
Colitis ischaemic1
COLITIS1
COLECTOMY1
CLOSTRIDIUM DIFFICILE COLITIS1
CLOSTRIDIUM COLITIS1
CLOSTRIDIAL INFECTION1
CLONUS1
CIRRHOSIS ALCOHOLIC1
CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR1
CIRCULATORY COLLAPSE1
Chronic sinusitis1
CHRONIC OBSTRUCTIVE AIRWAYS DISEASE EXACERBATED1
CHRONIC OBSTRUCTIVE AIRWAYS DISEASE1
CHRONIC MYELOMONOCYTIC LEUKAEMIA1
CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY1
CHRONIC HEPATITIS1
CHOLECYSTITIS CHRONIC1
CHEST X-RAY ABNORMAL1
Cervical vertebral fracture1
CERVICAL SPINAL STENOSIS1
CEREBROVASCULAR DISORDER1
CEREBRAL VENTRICLE DILATATION1
CEREBRAL ISCHAEMIA1
CEREBRAL CYST1
CEREBRAL ATROPHY1
CEREBRAL ARTERIOVENOUS MALFORMATION HAEMORRHAGIC1
CEREBELLAR ATROPHY1
CELLULITIS STAPHYLOCOCCAL1
CAROTID ENDARTERECTOMY1
CAROTID ARTERY STENOSIS1
CARDITIS1
CARDIOVERSION1
CARDIOTHORACIC RATIO INCREASED1
CARDIOGENIC SHOCK1
CARDIAC PACEMAKER INSERTION1
Cardiac operation1
CARDIAC HYPERTROPHY1
CARDIAC DEATH1
Campylobacter infection1
Calculus ureteric1
CALCULUS BLADDER1
CALCINOSIS1
C-REACTIVE PROTEIN INCREASED1
Bursitis1
BUNION1
BUNDLE BRANCH BLOCK1
BULIMIA NERVOSA1
BRONCHITIS CHRONIC1
BRONCHIAL CARCINOMA1
Breech presentation1
Breast cyst1
BREAST CANCER IN SITU1
BRAIN SCAN ABNORMAL1
BRAIN OEDEMA1
Brain neoplasm malignant1
BRAIN NEOPLASM1
Brain hypoxia1
BRAIN HERNIATION1
Bradyphrenia1
BOWEL SOUNDS ABNORMAL1
Bowel movement irregularity1
BONE NEOPLASM1
BONE MARROW OEDEMA1
BONE MARROW DEPRESSION1
BONE LESION1
BODY TEMPERATURE INCREASED1
BODY MASS INDEX INCREASED1
BLOOD URIC ACID DECREASED1
BLOOD TESTOSTERONE DECREASED1
BLOOD SODIUM DECREASED1
BLOOD PYRUVIC ACID INCREASED1
BLOOD PRESSURE INADEQUATELY CONTROLLED1
BLOOD PRESSURE FLUCTUATION1
BLOOD PRESSURE DIASTOLIC INCREASED1
BLOOD PRESSURE DIASTOLIC DECREASED1
BLOOD PH INCREASED1
BLOOD OSMOLARITY DECREASED1
Blood lactic acid1
Blood insulin increased1
BLOOD CREATININE DECREASED1
Blood count abnormal1
BLOOD CHLORIDE DECREASED1
BLOOD BICARBONATE DECREASED1
BLOOD ALKALINE PHOSPHATASE NORMAL1
BLINDNESS UNILATERAL1
Bladder spasm1
Bladder operation1
Bladder irritation1
Bladder fibrosis1
Bladder dysfunction1
BLADDER DISTENSION1
BLADDER DISCOMFORT1
Bladder cyst1
BLADDER CANCER STAGE I, WITHOUT CANCER IN SITU1
BLADDER CANCER STAGE I, WITH CANCER IN SITU1
BIOPSY BONE MARROW ABNORMAL1
BILIARY TRACT DISORDER1
BILIARY NEOPLASM1
BILIARY DILATATION1
BILIARY COLIC1
BILE DUCT STONE1
Basedow's disease1
BARIUM SWALLOW ABNORMAL1
BAND NEUTROPHIL COUNT INCREASED1
BACTERIURIA1
Bacterial vaginosis1
BACTERIAL TEST POSITIVE1
BACTERIAL INFECTION1
BACTERIA URINE IDENTIFIED1
BACILLUS INFECTION1
B-CELL LYMPHOMA1
AVULSION FRACTURE1
AUTOIMMUNE DISORDER1
Auricular swelling1
AURA1
ATYPICAL MYCOBACTERIAL INFECTION1
ATTENTION DEFICIT/HYPERACTIVITY DISORDER1
ATROPHY1
ATRIOVENTRICULAR BLOCK FIRST DEGREE1
ATRIOVENTRICULAR BLOCK COMPLETE1
Atrial thrombosis1
ATRIAL TACHYCARDIA1
Ataxia1
Aspiration tracheal1
ARTHROPOD STING1
ARTHROPOD BITE1
APPETITE DISORDER1
Appendicitis perforated1
APPENDICITIS1
APLASTIC ANAEMIA1
APHASIA1
APHAGIA1
Aortic valve stenosis1
AORTIC BYPASS1
ANTINUCLEAR ANTIBODY POSITIVE1
ANTI-PLATELET ANTIBODY POSITIVE1
ANTI-INSULIN ANTIBODY POSITIVE1
ANOXIC ENCEPHALOPATHY1
Anosmia1
ANGLE CLOSURE GLAUCOMA1
ANGIOSARCOMA1
ANGIOPLASTY1
ANENCEPHALY1
ANASTOMOTIC LEAK1
Anal incontinence1
ANAEMIA HAEMOLYTIC AUTOIMMUNE1
ANAEMIA FOLATE DEFICIENCY1
Amyotrophy1
Amyotrophic lateral sclerosis1
Amnestic disorder1
AMMONIA INCREASED1
AMENORRHOEA1
ALTERED VISUAL DEPTH PERCEPTION1
Alstroem syndrome1
ALPHA 1 FOETOPROTEIN INCREASED1
Allergic granulomatous angiitis1
ALCOHOLISM1
ALCOHOL POISONING1
ALANINE AMINOTRANSFERASE1
Ageusia1
Adverse reaction1
ADVERSE DRUG REACTION1
ADRENOCORTICAL INSUFFICIENCY ACUTE1
ADRENAL INSUFFICIENCY1
Adrenal gland cancer1
ADENOMA BENIGN1
Adenocarcinoma of colon1
ACUTE PRERENAL FAILURE1
ACUTE LEUKAEMIA1
Acute left ventricular failure1
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED1
ACETABULUM FRACTURE1
Accidental exposure to product by child1
Accidental exposure to product1
ACCIDENTAL DRUG INTAKE BY CHILD1
ABORTION THREATENED1
ABORTION MISSED1
ABORTION1
ABDOMINAL INFECTION1
Abdominal abscess1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
O95342 300 Bile salt export pump ABCBB_HUMAN
P00918 114 Carbonic anhydrase 2 CAH2_HUMAN
P27338 199.4 Amine oxidase [flavin-containing] B AOFB_HUMAN
P37231 62 Peroxisome proliferator-activated receptor gamma PPARG_HUMAN
Q07869 6680 Peroxisome proliferator-activated receptor alpha PPARA_HUMAN
Q8N5K1 4800
Q9NZ45 370 CDGSH iron-sulfur domain-containing protein 1 CISD1_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: carcinogenicity
LD50: 1000 mg/kg



External links:

ChEBML: CHEMBL595
DrugBank: DB01132